Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol
Identifieur interne : 000084 ( France/Analysis ); précédent : 000083; suivant : 000085Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol
Auteurs : Yaseen Arabi [Arabie saoudite] ; Hanan Balkhy [Arabie saoudite] ; Ali H. Hajeer [Arabie saoudite] ; Abderrezak Bouchama [Arabie saoudite] ; Frederick G. Hayden [États-Unis] ; Awad Al-Omari [Arabie saoudite] ; Fahad M. Al-Hameed [Arabie saoudite] ; Yusri Taha [Arabie saoudite] ; Nahoko Shindo [Suisse] ; John Whitehead [Royaume-Uni] ; Laura Merson [Viêt Nam] ; Sameera Aljohani [Arabie saoudite] ; Khalid Al-Khairy [Arabie saoudite] ; Gail Carson ; Thomas C. Luke [États-Unis] ; Lisa Hensley [États-Unis] ; Abdulaziz Al-Dawood [Arabie saoudite] ; Saad Al-Qahtani [Arabie saoudite] ; Kayvon Modjarrad [États-Unis] ; Musharaf Sadat [Arabie saoudite] ; Gernot Rohde [Pays-Bas] ; Catherine Leport [France] ; Robert Fowler [Canada]Source :
- SpringerPlus [ 2193-1801 ] ; 2015.
Abstract
As of September 30, 2015, a total of 1589 laboratory-confirmed cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization (WHO). At present there is no effective specific therapy against MERS-CoV. The use of convalescent plasma (CP) has been suggested as a potential therapy based on existing evidence from other viral infections. We aim to study the feasibility of CP therapy as well as its safety and clinical and laboratory effects in critically ill patients with MERS-CoV infection. We will also examine the pharmacokinetics of the MERS-CoV antibody response and viral load over the course of MERS-CoV infection. This study will inform a future randomized controlled trial that will examine the efficacy of CP therapy for MERS-CoV infection. In the CP collection phase, potential donors will be tested by the enzyme linked immunosorbent assay (ELISA) and the indirect fluorescent antibody (IFA) techniques for the presence of anti-MERS-CoV antibodies. Subjects with anti-MERS-CoV IFA titer of ≥1:160 and no clinical or laboratory evidence of MERS-CoV infection will be screened for eligibility for plasma donation according to standard donation criteria. In the CP therapy phase, 20 consecutive critically ill patients admitted to intensive care unit with laboratory-confirmed MERS-CoV infection will be enrolled and each will receive 2 units of CP. Post enrollment, patients will be followed for clinical and laboratory outcomes that include anti-MERS-CoV antibodies and viral load. This protocol was developed collaboratively by King Abdullah International Medical Research Center (KAIMRC), Gulf Cooperation Council (GCC) Infection Control Center Group and the World Health Organization—International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC-WHO) MERS-CoV Working Group. It was approved in June 2014 by the Ministry of the National Guard Health Affairs Institutional Review Board (IRB). A data safety monitoring board (DSMB) was formulated. The study is registered at
Url:
DOI: 10.1186/s40064-015-1490-9
PubMed: 26618098
PubMed Central: 4653124
Affiliations:
- Arabie saoudite, Canada, France, Pays-Bas, Royaume-Uni, Suisse, Viêt Nam, États-Unis
- Maryland, Virginie
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PMC:4653124Le document en format XML
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Box 22490, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan" sort="Balkhy, Hanan" uniqKey="Balkhy H" first="Hanan" last="Balkhy">Hanan Balkhy</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415254.3</institution-id><institution-id institution-id-type="ISNI">0000000417907311</institution-id><institution>Infection Control Department, King Abdullah International Medical Research Center,</institution><institution>King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Hajeer, Ali H" sort="Hajeer, Ali H" uniqKey="Hajeer A" first="Ali H." last="Hajeer">Ali H. 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Box 22490, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>P.O. Box 22490, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. 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City,</institution></institution-wrap>Al-Ahsa, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Al-Ahsa</wicri:regionArea></affiliation></author><author><name sortKey="Shindo, Nahoko" sort="Shindo, Nahoko" uniqKey="Shindo N" first="Nahoko" last="Shindo">Nahoko Shindo</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.3575.4</institution-id><institution-id institution-id-type="ISNI">0000000121633745</institution-id><institution>Pandemic and Epidemic Diseases Department,</institution><institution>World Health Organization,</institution></institution-wrap>Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Whitehead, John" sort="Whitehead, John" uniqKey="Whitehead J" first="John" last="Whitehead">John Whitehead</name><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="GRID">grid.9835.7</institution-id><institution-id institution-id-type="ISNI">0000000081906402</institution-id><institution>Department of Mathematics and Statistics,</institution><institution>Lancaster University,</institution></institution-wrap>Lancaster, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lancaster</wicri:regionArea></affiliation></author><author><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.412433.3</institution-id><institution-id institution-id-type="ISNI">0000000404296814</institution-id><institution>Oxford University Clinical Research Unit,</institution></institution-wrap>764 Vo Van Kiet Street, Ward 1, District 5, Ho Chi Minh City, Vietnam</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>764 Vo Van Kiet Street, Ward 1, District 5, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Aljohani, Sameera" sort="Aljohani, Sameera" uniqKey="Aljohani S" first="Sameera" last="Aljohani">Sameera Aljohani</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415254.3</institution-id><institution-id institution-id-type="ISNI">0000000417907311</institution-id><institution>Pathology and Laboratory Department,</institution><institution>King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Al Khairy, Khalid" sort="Al Khairy, Khalid" uniqKey="Al Khairy K" first="Khalid" last="Al-Khairy">Khalid Al-Khairy</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415254.3</institution-id><institution-id institution-id-type="ISNI">0000000417907311</institution-id><institution>Pathology and Laboratory Department,</institution><institution>King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name><affiliation><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution-id institution-id-type="ISNI">0000000419368948</institution-id><institution>University of Oxford Centre for Tropical Medicine 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Box 22490, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>P.O. Box 22490, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Qahtani, Saad" sort="Al Qahtani, Saad" uniqKey="Al Qahtani S" first="Saad" last="Al-Qahtani">Saad Al-Qahtani</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415254.3</institution-id><institution-id institution-id-type="ISNI">0000000417907311</institution-id><institution>Intensive Care Department, Respiratory Services, College of Medicine, King Abdullah International Medical Research Center,</institution><institution>King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City,</institution></institution-wrap>P.O. Box 22490, Riyadh, 11426 Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>P.O. Box 22490, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Modjarrad, Kayvon" sort="Modjarrad, Kayvon" uniqKey="Modjarrad K" first="Kayvon" last="Modjarrad">Kayvon Modjarrad</name><affiliation wicri:level="2"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="GRID">grid.420210.5</institution-id><institution-id institution-id-type="ISNI">0000000100364726</institution-id><institution>U.S. Military HIV Research Program,</institution><institution>Walter Reed Army Institute of Research,</institution></institution-wrap>Silver Spring, MD 20910 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Silver Spring</wicri:cityArea></affiliation></author><author><name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name><affiliation wicri:level="1"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="GRID">grid.415254.3</institution-id><institution-id institution-id-type="ISNI">0000000417907311</institution-id><institution>Intensive Care Department,</institution><institution>King Abdulaziz Medical City,</institution></institution-wrap>Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Rohde, Gernot" sort="Rohde, Gernot" uniqKey="Rohde G" first="Gernot" last="Rohde">Gernot Rohde</name><affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Respiratory Medicine,</institution><institution>Maastricht University Medical Center,</institution></institution-wrap>P. Debyelaan 25, 6202AZ Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>P. Debyelaan 25, 6202AZ Maastricht</wicri:regionArea><wicri:noRegion>6202AZ Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Leport, Catherine" sort="Leport, Catherine" uniqKey="Leport C" first="Catherine" last="Leport">Catherine Leport</name><affiliation wicri:level="1"><nlm:aff id="Aff17"><institution-wrap><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution-id institution-id-type="ISNI">0000000122170017</institution-id><institution>The French Infectious Disease Society,</institution><institution>Universite Paris Diderot,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Fowler, Robert" sort="Fowler, Robert" uniqKey="Fowler R" first="Robert" last="Fowler">Robert Fowler</name><affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution>Department of Medicine and Institute of Health Policy Management and Evaluation, AMR Infection Control and Publications AIP/PED/HSE/HQ,</institution><institution>University of Toronto,</institution></institution-wrap>Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="GRID">grid.413104.3</institution-id><institution-id institution-id-type="ISNI">0000000097431587</institution-id><institution>Department of Critical Care Medicine and Department of Medicine,</institution><institution>Sunnybrook Health Sciences Centre,</institution></institution-wrap>Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto</wicri:regionArea></affiliation></author></analytic><series><title level="j">SpringerPlus</title><idno type="eISSN">2193-1801</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">As of September 30, 2015, a total of 1589 laboratory-confirmed cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization (WHO). At present there is no effective specific therapy against MERS-CoV. The use of convalescent plasma (CP) has been suggested as a potential therapy based on existing evidence from other viral infections. We aim to study the feasibility of CP therapy as well as its safety and clinical and laboratory effects in critically ill patients with MERS-CoV infection. We will also examine the pharmacokinetics of the MERS-CoV antibody response and viral load over the course of MERS-CoV infection. This study will inform a future randomized controlled trial that will examine the efficacy of CP therapy for MERS-CoV infection. In the CP collection phase, potential donors will be tested by the enzyme linked immunosorbent assay (ELISA) and the indirect fluorescent antibody (IFA) techniques for the presence of anti-MERS-CoV antibodies. Subjects with anti-MERS-CoV IFA titer of ≥1:160 and no clinical or laboratory evidence of MERS-CoV infection will be screened for eligibility for plasma donation according to standard donation criteria. In the CP therapy phase, 20 consecutive critically ill patients admitted to intensive care unit with laboratory-confirmed MERS-CoV infection will be enrolled and each will receive 2 units of CP. Post enrollment, patients will be followed for clinical and laboratory outcomes that include anti-MERS-CoV antibodies and viral load. This protocol was developed collaboratively by King Abdullah International Medical Research Center (KAIMRC), Gulf Cooperation Council (GCC) Infection Control Center Group and the World Health Organization—International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC-WHO) MERS-CoV Working Group. It was approved in June 2014 by the Ministry of the National Guard Health Affairs Institutional Review Board (IRB). A data safety monitoring board (DSMB) was formulated. The study is registered at <ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</ext-link> (NCT02190799).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y Cheng</name></author><author><name sortKey="Wong, R" uniqKey="Wong R">R Wong</name></author><author><name sortKey="Soo, Yo" uniqKey="Soo Y">YO Soo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clopper, Cj" uniqKey="Clopper C">CJ Clopper</name></author><author><name sortKey="Pearson, Es" uniqKey="Pearson E">ES Pearson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Lee, Ck" uniqKey="Lee C">CK Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Lee, Ck" uniqKey="Lee C">CK Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kong, Lk" uniqKey="Kong L">LK Kong</name></author><author><name sortKey="Zhou, Bp" uniqKey="Zhou B">BP Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luke, Tc" uniqKey="Luke T">TC Luke</name></author><author><name sortKey="Kilbane, Em" uniqKey="Kilbane E">EM Kilbane</name></author><author><name sortKey="Jackson, Jl" uniqKey="Jackson J">JL Jackson</name></author><author><name sortKey="Hoffman, Sl" uniqKey="Hoffman S">SL Hoffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mair Jenkins, J" uniqKey="Mair Jenkins J">J Mair-Jenkins</name></author><author><name sortKey="Saavedra Campos, M" uniqKey="Saavedra Campos M">M Saavedra-Campos</name></author><author><name sortKey="Baillie, Jk" uniqKey="Baillie J">JK Baillie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, Km" uniqKey="Yeh K">KM Yeh</name></author><author><name sortKey="Chiueh, T" uniqKey="Chiueh T">T Chiueh</name></author><author><name sortKey="Siu, Lk" uniqKey="Siu L">LK Siu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Canada</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Viêt Nam</li><li>États-Unis</li></country><region><li>Maryland</li><li>Virginie</li></region></list><tree><noCountry><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name></noRegion><name sortKey="Al Dawood, Abdulaziz" sort="Al Dawood, Abdulaziz" uniqKey="Al Dawood A" first="Abdulaziz" last="Al-Dawood">Abdulaziz Al-Dawood</name><name sortKey="Al Hameed, Fahad M" sort="Al Hameed, Fahad M" uniqKey="Al Hameed F" first="Fahad M." last="Al-Hameed">Fahad M. Al-Hameed</name><name sortKey="Al Khairy, Khalid" sort="Al Khairy, Khalid" uniqKey="Al Khairy K" first="Khalid" last="Al-Khairy">Khalid Al-Khairy</name><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name><name sortKey="Al Qahtani, Saad" sort="Al Qahtani, Saad" uniqKey="Al Qahtani S" first="Saad" last="Al-Qahtani">Saad Al-Qahtani</name><name sortKey="Aljohani, Sameera" sort="Aljohani, Sameera" uniqKey="Aljohani S" first="Sameera" last="Aljohani">Sameera Aljohani</name><name sortKey="Balkhy, Hanan" sort="Balkhy, Hanan" uniqKey="Balkhy H" first="Hanan" last="Balkhy">Hanan Balkhy</name><name sortKey="Bouchama, Abderrezak" sort="Bouchama, Abderrezak" uniqKey="Bouchama A" first="Abderrezak" last="Bouchama">Abderrezak Bouchama</name><name sortKey="Hajeer, Ali H" sort="Hajeer, Ali H" uniqKey="Hajeer A" first="Ali H." last="Hajeer">Ali H. Hajeer</name><name sortKey="Sadat, Musharaf" sort="Sadat, Musharaf" uniqKey="Sadat M" first="Musharaf" last="Sadat">Musharaf Sadat</name><name sortKey="Taha, Yusri" sort="Taha, Yusri" uniqKey="Taha Y" first="Yusri" last="Taha">Yusri Taha</name></country><country name="États-Unis"><region name="Virginie"><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name></region><name sortKey="Hensley, Lisa" sort="Hensley, Lisa" uniqKey="Hensley L" first="Lisa" last="Hensley">Lisa Hensley</name><name sortKey="Luke, Thomas C" sort="Luke, Thomas C" uniqKey="Luke T" first="Thomas C." last="Luke">Thomas C. Luke</name><name sortKey="Modjarrad, Kayvon" sort="Modjarrad, Kayvon" uniqKey="Modjarrad K" first="Kayvon" last="Modjarrad">Kayvon Modjarrad</name></country><country name="Suisse"><noRegion><name sortKey="Shindo, Nahoko" sort="Shindo, Nahoko" uniqKey="Shindo N" first="Nahoko" last="Shindo">Nahoko Shindo</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Whitehead, John" sort="Whitehead, John" uniqKey="Whitehead J" first="John" last="Whitehead">John Whitehead</name></noRegion></country><country name="Viêt Nam"><noRegion><name sortKey="Merson, Laura" sort="Merson, Laura" uniqKey="Merson L" first="Laura" last="Merson">Laura Merson</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Rohde, Gernot" sort="Rohde, Gernot" uniqKey="Rohde G" first="Gernot" last="Rohde">Gernot Rohde</name></noRegion></country><country name="France"><noRegion><name sortKey="Leport, Catherine" sort="Leport, Catherine" uniqKey="Leport C" first="Catherine" last="Leport">Catherine Leport</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Fowler, Robert" sort="Fowler, Robert" uniqKey="Fowler R" first="Robert" last="Fowler">Robert Fowler</name></noRegion><name sortKey="Fowler, Robert" sort="Fowler, Robert" uniqKey="Fowler R" first="Robert" last="Fowler">Robert Fowler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000084 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000084 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= France
|étape= Analysis
|type= RBID
|clé= PMC:4653124
|texte= Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:26618098" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |